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Health • Europe • Ago 2020

Accelerating Therapy Development for COVID-19 and Future Coronavirus Threats

CARE (Corona Accelerated R&D in Europe), supported by Europe’s Innovative Medicines Initiative (IMI), is the largest undertaking of its kind dedicated to discovering and developing urgently needed treatment options for COVID-19 • The initiative is committed to a long-term understanding of the disease and development of therapies for COVID-19 and future coronavirus threats in addition to urgent efforts to repurpose existing therapies as potential immediate response • The CARE consortium will accelerate COVID-19 R&D by bringing together the leading expertise and projects of 37 teams from academic and non-profit research institutions and pharmaceutical companies into a comprehensive drug discovery engine.

CARE (Corona Accelerated R&D in Europe) a new consortium supported by the Innovative Medicines Initiative (IMI) public-private partnership announced its launch today to accelerate the discovery and development of urgently needed medicines to treat SARS-CoV-2, the virus that causes COVID-19. With a grant totaling € 77.7 million, CARE is funded by cash contributions from the European Union (EU) and cash and in-kind contributions from eleven European Federation of Pharmaceutical Industries and Associations (EFPIA) companies and three IMI-Associated Partners. CARE is a five-year project bringing together 37 partners from Belgium, China, Denmark, France, Germany, the Netherlands, Poland, Spain, Switzerland, the UK and the US, and is led by VRI-Inserm (French National Institute of Health and Medical Research, Paris, France), Janssen Pharmaceutica NV, one of the Janssen Pharmaceutical Companies of Johnson & Johnson (Beerse, Belgium), and Takeda Pharmaceuticals International AG, (Zurich, Switzerland). It integrates partners’ COVID-19 projects ongoing since February 2020.

“The COVID-19 pandemic has emerged as the largest global health threat to humanity in this century, requiring the global scientific community to join forces in unprecedented ways,” said Professor Yves Lévy, Executive Director of the VRI-Inserm and CARE coordinator. “Beyond the scientific excellence of the different teams involved in this very ambitious project, CARE is bringing together 37 partners in an alliance pooling their expertise and know-how around an ambitious five-year work plan to develop therapeutics against the current COVID-19 pandemic. We are very grateful for the financial support provided by the Innovative Medicine Initiative that will enable us to implement this plan.”

With no licensed vaccines and only limited therapy options against COVID-19, the pandemic is ongoing, counting more cases and deaths every day. Uniting some of the most innovative and experienced scientists from all relevant areas in a unique collaborative spirit CARE will maximize synergies and complementarities with other initiatives such as the Gates Foundation-supported COVID-19 Therapeutics Accelerator, MANCO(1), SCORE(2), and the ECRAID(3) network, to accelerate the path to providing solutions for the current COVID-19 pandemic as well as future coronavirus outbreaks. After testing in the laboratory, the project will advance the most promising drug candidates to clinical trials in humans.

We are very excited to launch the CARE consortium and collaborate with other leading experts to urgently identify new medicines against SARS-CoV-2 and other coronaviruses that may have the potential to cause epidemics,” added CARE project leader Marnix Van Loock, Senior Scientific Director and R&D Lead of Emerging Pathogens, Global Public Health, Janssen Pharmaceutica NV. “As part of this initiative, we look forward to applying learnings from an ongoing collaboration on COVID-19 with the Rega Institute for Medical Research, part of KU Leuven, to screen a drug repurposing library of thousands of existing drug compounds.”

Kumar Saikatendu, Ph.D., Director, Global Research Externalization, Takeda said “It is humbling to see such a large collection of the best scientific minds in Europe come together to solve this complex problem with such urgency. COVID-19 is a once in a lifetime scientific challenge for our generation. CARE aims to create effective therapies with a positive safety profile for current and future coronaviral outbreaks. We hope to move fast and have a meaningful impact in a timely manner.”

Comprehensive short- and long-term response to COVID-19

CARE aims to create effective therapies with a positive safety profile for the COVID-19 pandemic (drug repositioning), and develop new drugs and antibodies specially designed to tackle the SARS-CoV-2 virus.

The consortium builds on three pillars:

Closely integrated with these pillars are work streams focusing on the refinement of candidate compounds through a comprehensive medicinal chemistry campaign, systems biology research and pre-clinical and clinical evaluation of molecules from all three pillars. The systems biology work package will investigate the viral pathophysiology to increase our understanding of the interplay between virus infection stages and human immune responses. It will identify disease markers, to inform therapy development and improve clinical trial design and monitoring of Phase 1 and 2 trials investigating new therapeutics developed by CARE. • 8/20

1 Monoclonal Antibodies against 2019-New Coronavirus • 2 Swift Coronavirus therapeutics Response • 3 European Clinical Research Alliance on Infectious Diseases

Links: IMI (Innovative Medicines Initiative) • Boehringer Ingelheim

CARE is a new public-private partnership bringing together scientists from academia, research centers, Small Medium Enterprises (SMEs), European Federation of Pharmaceutical Industries and Associations (EFPIA) member companies and IMI Associated Partners. In total, it comprises 37 different partner organizations. Professor Yves Lévy from VRI-Inserm is the academic coordinator, Marnix Van Loock from the Janssen Pharmaceutical Companies of Johnson & Johnson is the EFPIA project leader and Kumar Saikatendu from Takeda is the project co-leader. The project partners are 11 academic institutions (KUL, GUF, AMU, UzL UU, EDI-IVI, UHAM, UEDIN, TiHo, JU, LUMC), five public research organisations (Inserm, CHUV, CEA, HZI, SERMAS) and 7 SMEs (IT, EVF, EXSCI, NUVISAN, SCIFEON, ENYO, AIB), together with eleven EFPIA members (Janssen, Takeda, Pfizer, ABBV, BI, Merck KgA, BAG, Novartis, Astellas, Servier and AiCuris), and three IMI2 Associated Partners (BMGF, UNIVDUN, GHDDI).*



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ODS • Sostenible • Ago 2020

Inversiones en el segmento de reciclaje avanzado

Sealed Air Corporation ha firmado un acuerdo de colaboración con Plastic Energy, una empresa líder en el sector de tecnologías de reciclaje avanzado • Además, Sealed Air ha realizado una inversión de capital en en Plastic Energy Global, la sociedad matriz de Plastic Energy

Plastic Energy Global se estableció en 2012 con el objetivo de crear una economía circular para los plásticos mediante la desviación de los derechos plásticos de los vertederos y los océanos. Con sede en Londres, la empresa cuenta con dos operacionessedes operativas en España y proyectos en desarrollo en Europa Occidental y Asia, con una visión de 50 nuevas instalaciones en los próximos 10 años.

“Estamos entusiasmados de aunarunir fuerzas con Plastic Energy para innovar más rápidamente y acelerar el desarrollo de nuevas tecnologías que eliminen los residuos y garanticen una economía circular para los plásticos”, afirmó Ted Doheny, Presidente y Director Ejecutivo de Sealed Air. “Esta colaboración nos ayudará a cumplir nuestro compromiso de sostenibilidad para 2025 y a liderar la transformación de nuestro sector”.

“Estamos encantados de iniciar esta nueva colaboración estratégica con Sealed Air, que conducirá a la aceleración del desarrollo de la industria del reciclaje avanzado, así como a proporcionar una solución circular para más y más plásticos”, indicó Carlos Monreal, fundador y Director Ejecutivo de Plastic Energy.

El desafío: combatir los residuos
Los residuos son un problema global. La mayoría de los residuos plásticos acaban en un vertedero, incinerados o desechados en el medio ambiente porque nunca se recuperan o se considera que no se pueden reciclar. Desde una perspectiva social es fundamental que ampliemos las opciones disponibles para reciclar plásticos.

La oportunidad
Plastic Energy cuenta con una plataforma tecnológica que permite alejar los residuos de plástico de los vertederos, con el objetivo de procesar 300.000 toneladas de plástico para 2025. Plastic Energy transforma los residuos de plásticos posconsumo en un nuevo producto reciclado que se puede utilizar para crear soluciones de envasado esenciales, incluido el embalaje protectorlos envases de protección para alimentos, facilitando así que el plástico se convierta en un nuevo recurso. Gracias a esta colaboración con Plastic Energy, Sealed Air está ayudandoayudará a eliminar los residuos plásticos, a proporcionar apoyo a enfoques complementarios de reciclaje y a permitir que sus clientes incorporen plásticos reciclados en sus envases.

Compromiso audaz y colaboración
Sealed Air está decidida a desempeñar un papel clave en el impulso hacia una economía circular para los plásticos mediante la colaboración, la investigación, el desarrollo y la implementación de nuevas tecnologías.

En 2018, Sealed Air anunció un audaz compromiso sobre sostenibilidad y plásticos, con la promesa de diseñar y promover soluciones de envasado que sean 100 por cien reciclables o reutilizables para 2025. Como parte del compromiso, la empresa tiene un ambicioso objetivo de un promedio de contenido reciclado del 50 % en todas las soluciones de envasado, con un 60 % procedente de productos reciclados posconsumo.

La promesa también También se incluye el compromiso de liderar colaboraciones con socios globales para incrementar las tasas de reciclaje y reutilización, en línea con la inversión en Plastic Energy. En 2019, Sealed Air también anunció que había aunadounido fuerzas con Alliance to End Plastic Waste (Alianza para acabar con los residuos plásticos), una organización mundial sin ánimo de lucro con el compromiso de invertir en soluciones para ayudar a eliminar los residuos plásticos en el medio ambiente. • 8/20


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